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What you need to know about Alzheimer

Alzheimer’s disease is the most common cause of dementia worldwide

Friday, September 14 2018

September is international Alzheimer's Month, an international campaign to raise awareness and challenge the stigma that surrounds dementia.

Alzheimer’s disease is the most common cause of dementia worldwide. Those over the age of 60 are most vulnerable to the illness, but it can occur in younger people too, especially when there is a family history of early-onset dementia.

The disease is progressive and dementia symptoms gradually worsen over a number of years. In its early stages, memory loss is mild, but with late-stage Alzheimer's, individuals lose the ability to carry on a conversation and respond to their environment.

“Alzheimer’s dementia (AD) differs from normal brain ageing,” says Dr Kim Laxton, a psychiatrist at Akeso Clinic. “With age, the brain, like any organ and muscle in the body, becomes weaker and less effective in its functioning, particularly in its cognitive capacity. Alzheimer’s dementia is a pathological ageing of the brain. Loss of memory and cognitive abilities is the most common symptom and, with time, the person becomes wholly dependent on others for the basic activities of daily living.” 
There is a genetic component that renders someone susceptible to the onset of the disease, She adds, but genetics is not the only factor involved in the development of older-age AD. “Certain genetic alleles, present in a person, might predispose them to AD, but other factors such as hypertension and high cholesterol are also implicated as risk factors.”

The Lancet published an article in 2017 describing high education levels, metabolic risk factor control and the early use of hearing aids in those with presbycusis (hearing loss) as being protective factors, against the development of the dementia illness.  Early stages of AD presents with word-finding and short-term memory difficulties, such as losing keys, forgetting to pay bills, forgetting names of people and objects, and becoming lost in familiar places.
“Two abnormal structures called plaques and tangles are prime suspects in damaging and killing nerve cells in the brain,” says Laxton. “Though autopsy studies show that most people develop some plaques and tangles as they age, those with Alzheimer’s tend to develop far more and in a predictable pattern, beginning in the areas important for memory before spreading to other regions.”

Signs and symptoms
Life expectancy is between 5 and 10 years after the onset of the initial symptoms of Alzheimer’s. In the early stages of the disease the patient often does not realise the memory concerns, and a family member is usually the first to notice subtle changes in the patient’s ability to function.
“Over time the person may begin to display changes in their behaviour and personality. Wandering in the neighbourhood and during the night, as well as aggressive outbursts, become significant concerns for the family. Nursing homes and residential facilities are available to manage the behavioural and psychological aspects of the advanced illness. Essentially, over time, the patient requires increasing assistance from others to be able to perform simple activities of daily life, such as bathing, toileting and feeding.”

The illness renders the patient dependent on others. In the early stages, they might feel confused, irritable and even depressed, Laxton notes. Slowly but surely, previously basic tasks become more difficult. The patient may feel cumbersome and vulnerable.
“Over time the patient may lose insight and struggle to function within their environment without the head knowledge that there is a decline in functioning. However, it is believed that, despite the deteriorating mental capacity of the patient, there is a deep sense of loss that parts of oneself are declining.”

Diagnosis and treatment
The diagnosis of AD is essentially a clinical one. A doctor, predominantly a neurologist, geriatrician and/or psychiatrist, will take a thorough history, perform a physical examination and administer bedside screening questionnaires, one being the Folstein’s Mini-Mental State Examination (MMSE).

“It is important that the doctor treat any underlying medical and/or psychiatric illness that could potentially mimic the symptoms of Alzheimer’s Dementia, such as a major depressive disorder,” Laxton says.  “Blood investigations routinely performed are those for thyroid function, vitamin B12, syphilis and HIV screening. This forms an important part of the workup as certain illnesses, such as hypothyroidism, can be treated, thus improving the patient’s overall cognitive functioning.”
The doctor may request that the patient has radiological investigations – such as a CT and/or MRI-Brain which may assist in excluding other neurological illnesses – to stage the disease, especially in the latter part of the dementing process.

“The treatment of AD does not cure the illness but it may slow the progression of the disease,” she adds. “There are currently clinical trials underway in Johannesburg that are attempting to screen patients and intervene early in those who are susceptible to the disease and are in the earliest clinical stages of the illness. However, the inclusion criteria are very specific; both the patient and their support structure are interviewed and assessed methodically and regularly, prior to medication trial being administered.”

Where to seek help
The most tragic part of the disease is the effect that it has on family and loved ones. “The human being, with their personality traits, quirks and identity, subtly disintegrates over time,” Laxton explains. “The once complete and unique person transforms into a brittle shell and, toward the end of the disease, is often unrecognisable, and wholly dependent on others.”

If you are concerned that a family member or friend might be showing early signs of the disease, encourage them to see a GP as a starting point. Diagnosing dementia is a very delicate process, Laxton says. Once the diagnosis has been documented, the lives of others transform immediately.
“Doctors provide the patient and the family with information pertaining to the disease itself, what to expect over time, and the various support groups and resources that should be used, especially in the cases of advanced disease. Caregiver burden and guilt are common, and all those who are living with a person who has the diagnosis of AD, should be judiciously supported.”

“Any person who has a loved one who has been diagnosed with AD should remember this: never forget to love. Holding someone’s hand, just this physical touch of warmth, is worth more than words or medications.” 
For further information regarding Alzheimer’s Dementia, visit Alzheimers.org.za and Dementiasa.org.
Facts and figures

  • Alzheimer’s dementia (AD) is evident in both the developed and developing world and is the cause of up to 75% of all dementias globally.
  • The most important risk factor for the development of Alzheimer’s disease is age. With an ageing population that is growing substantially as a result advancing medicine and lifestyle enhancements, there is an expected increase in the number of AD patients.
  • AD in those over the age of 65 years is expected to increase from 420 million in the year 2000 to nearly 1 billion by 2030, by the proportion of older people seeing an increase from 7% to 12%.  
  • The prevalence rate percentages show an increasing trend of the number of AD diagnoses made as age increases. The prevalence rate in the 65-69 year age group is about 1.4% and increases to 23.6% in those 85 years and older.
  • According to South Africa’s 2011 census, there are approximately 2.2 million people in South Africa with this particular form of Dementia. 

References:

  • https://www.alz.org/alzheimers-dementia/what-is-alzheimers
  • American Psychiatric Association, 2013. Diagnostic and statistical manual of mental disorders (DSM-5®). American Psychiatric Pub.
  • Alzheimer’s, A., 2015. 2015 Alzheimer's disease facts and figures. Alzheimer's & dementia: the journal of the Alzheimer's Association11(3), p.332.
  • Hendrie, H.C., 1998. Epidemiology of dementia and Alzheimer's disease. The American Journal of Geriatric Psychiatry6(2), pp.S3-S18.
  • Livingston, G., Sommerlad, A., Orgeta, V., Costafreda, S.G., Huntley, J., Ames, D., Ballard, C., Banerjee, S., Burns, A., Cohen-Mansfield, J. and Cooper, C., 2017. Dementia prevention, intervention, and care. The Lancet390(10113), pp.2673-2734.
  • Kalaria, R.N., Maestre, G.E., Arizaga, R., Friedland, R.P., Galasko, D., Hall, K., Luchsinger, J.A., Ogunniyi, A., Perry, E.K., Potocnik, F. and Prince, M., 2008. Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors. The Lancet Neurology7(9), pp.812-826.
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